Antibiotics · Prescription (Rx)
Zuprevo withdrawal time for cattle
tildipirosin. Used for bRD treatment and control — single-dose macrolide.
Slaughter withdrawal
21 days
| Route / formulation | Slaughter withdrawal | Detail |
|---|---|---|
| Subcutaneous injection (single dose) | 21 days |
Milk & dairy: Not approved for female dairy cattle 20 months of age or older; no withdrawal established for pre-ruminating calves.
Zuprevo is the third single-dose macrolide in the BRD lineup, sitting between Draxxin (18 days) and Zactran (35 days) with a 21-day U.S. slaughter withdrawal. Note the country matters: the Canadian label for the same product is 42 days — a reminder to read the bottle in your hand, not a chart from another market.
One label warning worth knowing even on a cow-calf place: tildipirosin is fatal to swine. Never use it in pigs, and keep it away from any operation that runs both.
What the label requires
- U.S. slaughter withdrawal: 21 days (Canada’s label is 42 — country labels differ).
- Fatal to swine — never use or store where it could reach pigs.
- Single-dose SQ in the neck.
Always follow the label on your bottle and your veterinarian's directions. Extra-label use — any different dose, route, or frequency — voids the withdrawal above; your vet sets the interval instead, usually via FARAD. When in doubt, hold longer. Label data checked July 18, 2026. Source: FDA label (DailyMed).
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Log a treatment in HerdCommand with its withdrawal days and the animal carries a hold flag until the date clears — and the sale workflow warns you before a flagged animal ends up on a load. Works from the phone in your pocket, at the chute.
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Common questions
Why do U.S. and Canadian withdrawal times differ for the same drug?
Each country’s regulator sets its own residue tolerances, and lower tolerances mean longer withdrawals. Zuprevo is 21 days in the U.S. and 42 in Canada. Always use the label printed on your bottle for your country.